ACN Newswire

TOKYO, Sep 8, 2017 - (JCN Newswire) - Eisai Co., Ltd. and Ono Pharmaceutical Co., Ltd. have announced that they have entered into a collaboration agreement to jointly develop the combination therapy of Eisai's multi-kinase inhibitor, Lenvima (lenvatinib mesylate) and Ono's human anti-human PD-1 (programmed cell death-1) monoclonal antibody, Opdivo (nivolumab) for the treatment of hepatocellular carcinoma (HCC) .

Based on this agreement, Eisai and Ono will swiftly implement a Phase Ib clinical trial in Japan to investigate the safety, tolerability, and efficacy of the combination of Lenvima and Opdivo in patients with HCC. Details relating to the financial and other conditions of this agreement are confidential.

Liver cancer is the second most common cause of cancer related deaths, with an estimated 750,000 deaths per year globally.(1) Additionally, 780,000 cases are newly diagnosed each year, about 80% of which occur in Asian regions, including Japan and China.(1) HCC accounts for approximately 85% to 90% of liver cancer cases. It is estimated that there are approximately 42,000 HCC patients in Japan,2 with 26,000 deaths per year.(3) Treatment options for unresectable HCC are limited and the prognosis is very poor, so this remains an area with high unmet medical needs. Eisai submitted an application for an additional indication of Lenvima for the treatment of HCC in Japan in June 2017. Ono is currently conducting a Phase III clinical trial of Opdivo for the treatment of HCC in Japan.

Dr. Takashi Owa, Vice President, Chief Medicine Creation Officer, Oncology Business Group, Eisai, commented, "Our non-clinical research has demonstrated synergistic antitumor activities in the Lenvima and anti-PD1 antibody combination, which are considered to be a result of an immunostimulatory response through a reduction in immunosuppressive tumor-associated macrophages and an increase in cytotoxic T lymphocytes by Lenvima. Through the development of a combination therapy that has the potential to produce synergistic effects between Lenvima and nivolumab, both drugs of Japanese origin, we anticipate being able to further contribute to addressing the high unmet medical needs of HCC patients and their families and improving their benefits."

Hiroshi Awata, Vice President Executive Officer / Executive Director, Clinical Development, Ono, commented, "We have been actively engaged in the development of Opdivo not only in monotherapy, but combination therapies with other agents. As we believe that the combination therapy may exert more excellent therapeutic efficacy compared to the monotherapy, we are very pleased to pursue the potential for developing the combination therapy of Opdivo with lenvatinib. We expect that the combination therapy with Opdivo and lenvatinib will be a new treatment option for the patients with hepatocellular carcinoma."

About Lenvima (lenvatinib mesylate)

Discovered and developed in-house, lenvatinib is an orally administered multiple receptor tyrosine kinase (RTK) inhibitor with a novel binding mode that selectively inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors (VEGFR1, VEGFR2 and VEGFR3) and fibroblast growth factor (FGF) receptors (FGFR1, FGFR2, FGFR3 and FGFR4) in addition to other proangiogenic and oncogenic pathway-related RTKs (including the platelet-derived growth factor (PDGF) receptor PDGFRalpha; KIT; and RET) involved in tumor proliferation. Currently, Eisai has obtained approval for lenvatinib as a treatment for refractory thyroid cancer in over 50 countries, including the United States, Japan, and in Europe. Additionally, Eisai has obtained approval for the agent in combination with everolimus as a treatment for renal cell carcinoma (second-line) in over 35 countries, including the United States and in Europe. In Europe, the agent was launched under the brand name Kisplyx for renal cell carcinoma. The submission of applications in Japan (June 2017), the United States and Europe (July 2017), Eisai also plans to submit an application for lenvatinib for the treatment of HCC in China within the latter half of fiscal 2017. Furthermore, a Phase III study of lenvatinib in separate combinations with everolimus and pembrolizumab in renal cell carcinoma (first-line) was initiated and is underway. A Phase Ib/II study to investigate the agent in combination with pembrolizumab in select solid tumors (non-small cell lung cancer, renal cell carcinoma, endometrial cancer, urothelial cancer, head and neck cancer, and melanoma) and a Phase Ib study in HCC are also underway.

About Opdivo (nivolumab)

Opdivo is a PD-1 immune checkpoint inhibitor that uses the body's immune system to help restore antitumor immune response. In Japan, Ono launched Opdivo for the treatment of unresectable melanoma in September 2014. Ono received an approval for additional indication of unresectable, advanced or recurrent non-small cell lung cancer in December 2015, unresectable or metastatic renal cell cancer in August 2016, relapsed or refractory classical Hodgkin lymphoma in December 2016 and recurrent or metastatic head and neck cancer in March 2017. In addition, ONO has submitted supplemental application for additional indication of gastric cancer, and is conducting clinical development program including esophageal cancer, gastro-esophageal junction cancer, small cell lung cancer, hepatocellular carcinoma, glioblastoma, urothelial cancer, malignant pleural mesothelioma, ovarian cancer, biliary tract cancer, etc. Opdivo is currently approved in more than 60 countries, including the US, Europe, South Korea and Taiwan.

(1) GLOBOCAN2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/
(2) Ministry of Health, Labour and Welfare, 2014 Patient Survey 3 Ministry of Health, Labour and Welfare, 2014 Population Trends Survey

About Ono Pharmaceutical Co., Ltd.

Ono Pharmaceutical Co., Ltd., headquartered in Osaka, is an R&D-oriented pharmaceutical company committed to creating innovative medicines in specific fields. It focuses especially on oncology and diabetes. For further information., please visit the company's website at http://www.ono.co.jp/eng/.

About Eisai

Eisai Co., Ltd. (TSE:4523; ADR:ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit www.eisai.com.

Contact:
Public Relations Department,
Eisai Co., Ltd.
+81-3-3817-5120

- Project will be largest energy storage system in Switzerland -

TOKYO, Sep 8, 2017 - (JCN Newswire) - NEC Corporation and NEC Energy Solutions (NEC ES), a wholly-owned subsidiary of NEC, announced today that NEC ES is supplying Switzerland-based Elektrizitatswerke des Kantons Zurich (EKZ) with an 18 MW, 7.5 MWh GSS Grid Storage Solution. Once completed in early 2018, this project will be the largest battery energy storage system in Switzerland*. It will be owned and operated by EKZ, one of Switzerland's largest power distribution companies.

"We strongly believe that battery storage will play a key role in tomorrow's power networks. With this first large-scale commercial battery storage project performing primary reserve in Switzerland, we're taking an important step towards a reliable and sustainable energy future," said Marina Gonzalez Vaya, project manager for EKZ. "NEC ES's fast, flexible energy storage product proved to be the best solution to complement conventional power production assets, such as pumped hydro storage and thermal generation resources, in the primary reserve control market."

EKZ has an excellent track record with energy storage since 2012 with their 1 MW energy storage project in Dietikon, which became the first active battery energy storage system in Europe in the primary reserve control market without the backup of a conventional power plant. The new 18 MW battery energy storage system will be built at an existing substation in Volketswil, near Zurich, and will have the capacity equivalent to the daily electricity consumption of 600 average four-person households.

"We are very pleased that EKZ has chosen NEC for Switzerland's largest energy storage project," said Adam Briggs, Chief Commercial Officer for NEC Energy Solutions. "EKZ, like other customers around the world, is putting their trust in NEC to deliver superior, end-to-end energy storage solutions from concept to design, installation, commissioning and servicing to ensure the maximum return on investment for the life of their system."

*According to NEC research as of September 8, 2017

About EKZ

We help to shape the future of energy by reducing our customers' energy worries: we offer 100 percent renewable energy, some of the lowest electricity prices in Switzerland, and solutions for the future. We are one of Switzerland's biggest energy suppliers, providing nearly a million people with electricity. Our 1,400 employees are committed to helping homeowners and tenants, small, medium-sized and large businesses as well as other Swiss energy suppliers to find the most suitable energy solutions. Our electricity grid stretches over about 15,000 km, and its availability, at 99.997 percent, is above average.

About NEC Energy Solutions

NEC Energy Solutions designs, manufactures, and integrates smart energy storage solutions for the electric grid, behind the meter, and critical power applications. Its scalable distributed energy storage and control systems provide greater grid stability and flexibility to the benefit of both providers and users of electricity. In telecom, datacenter, and other industrial applications, its high performance lithium-ion battery systems provide better value than traditional lead-acid batteries in tough, critical power applications. Learn more at www.neces.com.

About NEC Corporation

NEC Corporation is a leader in the integration of IT and network technologies that benefit businesses and people around the world. By providing a combination of products and solutions that cross utilize the company's experience and global resources, NEC's advanced technologies meet the complex and ever-changing needs of its customers. NEC brings more than 100 years of expertise in technological innovation to empower people, businesses and society. For more information, visit NEC at http://www.nec.com.

Based on its Mid-term Management Plan 2015, the NEC Group globally provides "Solutions for Society" that promote the safety, security, efficiency and equality of society. Under the company's corporate message of "Orchestrating a brighter world," NEC aims to help solve a wide range of challenging issues and to create new social value for the changing world of tomorrow. For more information, please visit http://www.nec.com/en/global/about/solutionsforsociety/message.html.

Contact:
NEC 
Seiichiro Toda         
s-toda@cj.jp.nec.com 
+81-3-3798-6511

TOKYO, Sep 8, 2017 - (JCN Newswire) - NEC Corporation announced today the release of its Annual Environmental Report 2017 and its Corporate Social Responsibility (CSR) Report 2017, reflecting the activities and the achievements supporting the Environment, Society and Government (ESG) from April 1, 2016 to March 31, 2017 (hereafter FY2017).

The Annual Environmental Report shares common purpose with global environmental movements such as the Paris Agreement and Sustainable Development Goals(1), and highlights NEC's Long-Term Environmental Plan (NEC Group Environmental Management Action Plan 2020/2030) announced in July 2016(2), as well as the progress towards environmental management goals announced in July 2014(3) as part of addressing climate change.

The CSR Report provides an outline of activities and goals in pursuit of sustainable management, focusing on society and governance. As society's expectations towards global enterprises such as NEC increase, NEC has begun to prioritize sustainable development in cooperation with experts in the field, including activities that address human rights and supply chain management. Please see below for further detail on these initiatives.

Environmental Activities

1. Progress for the NEC Group Environmental Management Action Plan 2020/2030
NEC is focusing on the following three areas in order to address environmental issues and implement climate change countermeasures.

1) Contributing to mitigation of climate change:
- Reduction in CO2 emissions through the provision of IT solutions
- Cumulative reduction of 14 million tons in FY2017 (Target: 23 million tons in 2020)
- Improvement in product energy efficiency (compared with products in FY2014)
- Improvement rate of 30% in FY2017 (Target: 30% improvement in 2020)
2) Reducing the impact of climate change:
NEC promoted solutions to reduce the impact of climate change in FY2017, including the creation of three Eco-Symbol Star solutions.
3) Reduction of emissions from business activities:
- Improve CO2 emissions through higher product energy efficiency and switching to renewable energy sources.
9.5% improvement in FY2017 compared with in FY2013 (Target: 18% improvement in 2020 compared with FY2013)
- Switch to renewable energy.
- 6.9-fold increase in FY2017 compared with FY2012 (Target: 10-fold increase in 2020 compared with FY2012)

2. Progress on achieving climate change objectives for FY2021's goals(3)
In FY2017, NEC contributed to reducing CO2 emissions by attaining a level of CO2 reduction that is 2.4 times(4) the total volume of CO2 emissions from our entire supply chain in FY2017 by providing Solutions for Society. (Target in FY2021: 5 times.)

Activities for society and governance

NEC prioritizes the sustainable development of both society and the NEC Group under the theme of "materiality." As part of this, NEC has been improving performance outside of the financial field and ensuring the soundness of management. Within this transforming business environment, and corresponding to the expectations of society, NEC started to review materiality in FY2017 and to reconfirm its contributions.

NEC's CSR Report features dialogue between experts, NEC executives and employees on sustainable management, society and investment in order to capitalize on this knowledge and improve sustainable management.

The NEC Group globally provides "Solutions for Society" that promote safety, security, efficiency and equality, helping to create a society where people live more fulfilling lives through the fusion of advanced ICT and knowledge.

(1) Sustainable Development Goals consist of 17 goals on issues such as poverty, hunger, energy, climate change and peace. Efforts to attain these goals started in 2015 through 2030 after they were adopted by 193 member states at the United Nations Summit held in September 2015.
(2) NEC's Long-Term Environmental Plan (NEC Group Environmental Management Action Plan 2020/2030)
http://www.nec.com/en/global/eco/announce/environmental-plan/index.html
(3) NEC Announces New Environmental Management target reflecting climate change reduction measures through the Social Solutions business. (Press release on 8 July 2014)
http://www.nec.com/en/press/201407/global_20140708_02.html
(4) Please refer to the following calculation formula.
Calculation: ((2)14 million tons + (3)4.53 million tons) / (1)7.76million tons
(1) Impact of the environment for the total supply chain (Scope 1, 2, 3): 7.76 million tons.
(2) Contributing to mitigation of climate change: 14 million-tons.
(3) Contribution to reducing climate change(*): 4.53 million tons
*The result is not the real volume of the reduced CO2 but the value of CO2 after adaptation.

About NEC Corporation

NEC Corporation is a leader in the integration of IT and network technologies that benefit businesses and people around the world. By providing a combination of products and solutions that cross utilize the company's experience and global resources, NEC's advanced technologies meet the complex and ever-changing needs of its customers. NEC brings more than 100 years of expertise in technological innovation to empower people, businesses and society. For more information, visit NEC at http://www.nec.com.

Based on its Mid-term Management Plan 2015, the NEC Group globally provides "Solutions for Society" that promote the safety, security, efficiency and equality of society. Under the company's corporate message of "Orchestrating a brighter world," NEC aims to help solve a wide range of challenging issues and to create new social value for the changing world of tomorrow. For more information, please visit http://www.nec.com/en/global/about/solutionsforsociety/message.html.

Contact:
NEC 
Seiichiro Toda         
s-toda@cj.jp.nec.com 
+81-3-3798-6511

Kain Picken (centre) and Fiona Lau (right), Creative Directors of FFIXXED STUDIOS, share their experience and insights at the 7 September seminar "Master Sharing Series: A Dialogue with FFIXXED STUDIOS: A Creative Take on the 'Everyday'," which was moderated by Professory Cory Quach, Professor of Fashion Marketing & Management, SCAD Hong Kong (left). The seminar was held during the second edition of Asia's premier fashion event, CENTRESTAGE, organised by the Hong Kong Trade Development Council.

FFIXXED STUDIOS Forum Follows Gala Fashion Show

HONG KONG, Sep 8, 2017 - (ACN Newswire) - Having had no formal training as a fashion designer has not been a deterrent for Kain Picken - one half of the award-winning Hong Kong label, FFIXXED STUDIOS.

Mr Picken, along with design partner Fiona Lau, took part in the 7 September seminar "Master Sharing Series: A Dialogue with FFIXXED STUDIOS: A Creative Take on the 'Everyday'," held during the second edition of Asia's premier fashion event, CENTRESTAGE. The art graduate said that his and his partner's fashion background have given their brand, based in Hong Kong and Shenzhen, a unique perspective.

"One thing that has made our brand develop differently, compared with new younger brands - particularly some Chinese and Hong Kong brands - is we were already looking at fashion from the outside to start with," said Mr Picken.

Duo thrive on different skill sets

The couple's different skills have served them well, he said. "One advantage is you can leave out some of the baggage that comes with not having formal training. On the downside, that knowledge and expertise is sometimes really useful. [But] we both fill in the bits missing from the other person. With me having no technical training, Fiona can fill in the gaps, and vice versa."

The seminar was part of a series of designer-sharing sessions during the four-day CENTRESTAGE, organised by the Hong Kong Trade Development Council (HKTDC), at the Hong Kong Convention and Exhibition Centre.

The forum was held one day after the designers presented their 2018 Spring/Summer collection at the opening gala fashion show, CENTRESTAGE ELITES. The show also spotlighted the latest creations of Korean design master Juun.J, whose debut Hong Kong runway show was made possible through the collaboration of the brand's partner, JOYCE, and the HKTDC.

The Hong Kong and Shenzhen-based couple will next focus on their 2018 collection, which is scheduled to be available early next year in stores in Hong Kong, the mainland, Japan, Korea, the United States, Sweden, Germany, Norway and the United Arab Emirates.

Art project led to ready-to-wear brand

The Australian designers founded FFIXXED STUDIOS in 2010, two years after collaborating on an art project exploring different ideas and materials related to fashion. The project evolved into a ready-to-wear fashion brand and they released their first ready-to-wear product in 2009.

"Coming from an art background, one of the things that drew me into fashion was the idea that there's such a personal engagement with the object, about it being really part of your daily life. That's something you don't have with art," said Mr Picken.

The couple's ready-to-wear collections are designed for contemporary living and evolve seasonally in response to ideas at work and home. The designers have made the movement and openness of their clothing a priority - conceptually and also in material and functional terms.

They also place emphasis on modern cutting with a fluid eclectic aesthetic and use natural and recycled fibres and custom-developed fabrics as part of continuing efforts to support sustainability and ethical working processes.

Everyday items inspire design details

Ms Lau said they like to use simple everyday items as inspiration for their designs. In their latest collection, for example, they added fruit stickers onto transfer prints and the detailing of their clothes, while using the size and shape of dust bags as the template for garment pockets and leather bags. The couple have also used beads from taxi driver's massage chair for the design of a pair of reflexology sandals.

In the same way that jewels were used to embellish clothes, the couple decorated one of their garments with small buttons made from a lightweight compound so they resemble little rocks with holes cut in the centre. "No one looking at them would know they took hours to make," she said.

Mr Picken added: "The idea that something that is totally mundane or has no value can be re-thought in terms of its aesthetic value or functional value, is interesting."

The talk, moderated by Cory Quach, Professor of fashion marketing at the Savannah College of Art and Design in Hong Kong, included advice to fashion design students on how to break into the profession.

Internships invaluable for gaining experience

"Doing internships is really useful for helping you to make sense of what is involved, so you understand all aspects of fashion design," said Ms Lau. "After graduating, I wasn't sure about my next step. Luckily after my internship it made sense. I realised how to make my ideas into a finished product."

She also advised students to serve internships at various places in order to learn how companies operate differently.

"Some kids come out of school already with a clear picture about their fashion brand," said Mr Picken. "But if you don't have a clear picture or plan about your brand, then industry experience is the only way - and it is invaluable.

"A benefit of coming to a small company like us is that you see the big picture. If interns do the full cycle, they see everything - from the design development, the sampling, sales, show, production. You can tell people, but you need to see it to grasp it."

The duo's collections have shown at Paris and Shanghai Fashion weeks and have won several accolades, including the Hong Kong Young Talent Design Award in 2012 and the International Woolmark Prize - Women's Asia in 2013.

CENTRESTAGE, which features more than 210 fashion brands from 22 countries and regions, along with nearly 40 fashion events, including more than 20 fashion shows, debuted last year as a new promotion and launch platform for international fashion brands and designs - particularly those in Asia, reaffirming Hong Kong as the region's fashion capital.

Under the theme "Nouveau Playhouse," this year's CENTRESTAGE - one of the activities celebrating the 20th anniversary of the establishment of the HKSAR - features three thematic zones, GLAM, ALLURE and METRO.

Leading international brands taking part

Exhibiting fashion brands from the Chinese mainland, Taiwan, Australia, France, India, Italy, Japan, Korea, Sweden, Thailand, Britain and the United States, include BARBARA DI DAVIDE - I CASHMERE, CHENG PAI CHENG, Edward Achour, GLAMOROUS, KEEPSAKE, N12H and Zero Design, along with local brands anagram, Angus Tsui, HARRISON WONG, izzue and Yi-ming.

The HKTDC has organised 34 buying missions to visit the show, bringing buyers from more than 1,000 companies from 25 companies and regions, including Galeries Lafayette from France, Andreas Murkudis from Germany, Shinsegae from Korea, Isetan from Japan, select shops DONGLIANG and AnyShopStyle from the Chinese mainland, Breeze Center from Taiwan and local retailers such as Lane Crawford, Harvey Nichols, D-mop, DFS and Club 21.

Hong Kong in Fashion

The Hong Kong in Fashion citywide campaign is underway to spread the fashion buzz to the wider community. More than 90 fashion-related activities are being staged around Hong Kong from 15 August - 30 September. The campaign has been organised in collaboration with over 100 partners, including high-end hotels, shopping malls, fashion boutiques, restaurants and design institutes.

CENTRESTAGE becomes "OPENSTAGE" on the final day, when it will welcome public visitors aged 12 and above free of charge. A series of events, including a fashion parade, lifestyle tips-sharing, make-up and nail-art demo, will be arranged. Members of the public will have the chance to experience this major international fashion event and check out the latest designs from leading brands.

CENTRESTAGE website: http://centrestage.com.hk
The Hong Kong Young Fashion Designers' Contest 2017 (YDC) website: http://www.fashionally.com
CENTRESTAGE schedule: http://centrestage.com.hk/en/event/schedule.php
Hong Kong in Fashion schedule: http://centrestage.com.hk/files/page/36/17_centrestage_guidemap_op-02.jpg
Fashion Summit (HK) 2017: http://fashionsummit.hk/
Photo Download: http://bit.ly/2wb8zfD

About FASHIONALLY.com
The HKTDC launched the FASHIONALLY.com online platform in early 2012 to provide a unique networking and exchange platform for global fashion experts to connect, inspire and share information.

For Media:
Media representatives wishing to cover CENTRESTAGE may register on-site with their business cards and/or media identification.

About HKTDC

Established in 1966, the Hong Kong Trade Development Council (HKTDC) is a statutory body dedicated to creating opportunities for Hong Kong's businesses. With more than 40 offices globally, including 13 on the Chinese mainland, the HKTDC promotes Hong Kong as a platform for doing business with China, Asia and the world. With 50 years of experience, the HKTDC organises international exhibitions, conferences and business missions to provide companies, particularly SMEs, with business opportunities on the mainland and in international markets, while providing information via trade publications, research reports and digital channels including the media room. For more information, please visit: www.hktdc.com/aboutus. Follow us on Google+, Twitter @hktdc, LinkedIn.
- Google+: https://plus.google.com/+hktdc
- Twitter: http://www.twitter.com/hktdc
- LinkedIn: http://www.linkedin.com/company/hong-kong-trade-development-council

Contact:
HKTDC
Communication and Public Affairs Department
Joe Kainz
Tel: +852 2584 4216
Email: joe.kainz@hktdc.org

Reinforces Global Presence to Satisfy Rising Demand from High-growth Cloud Datacom Market

HONG KONG, Sep 8, 2017 - (ACN Newswire) - O-Net Technologies (Group) Limited ("O-Net" or the "Group") (stock code: 877), a leading high-technology enterprise, announced that it has shipped 250,000 pieces of 25GbE, 40GbE and 100GbE Active Optical Cable ("AOC") to major data center and network equipment manufacturer customers, marking a new milestone for the Group in satisfying the increasing demand from global web-scale operators.

AOC, which integrates multimode optical fiber, semiconductor laser and receivers, control chips and modules, boasts high performance, low power consumption and cost-effectiveness. AOC has a wide range of applications, particularly in enabling data centers to take advantage of the lower cost of ownership and foster high-speed data transmission for meeting diverse applications. And, the 25GbE, 40GbE and 100GbE AOC can speed up data communication in a cloud data center, especially those of international Internet service providers and other major cloud facility and service players. The shipment is proof of the global recognition that the Group enjoys for its innovative next-generation products; also, the foresight of its management has strengthened the leading position of the Group in the industry.

Mr. Austin Na, Chairman and CEO of O-Net, said, "I am delighted that we are able to make the shipment in a relatively short period after receiving the orders. It has given us the reason to be optimistic about the performance of our optical networking products business in the second half of this year. With the increasing demand for higher speed cloud services, we are confident that the high-speed AOC will become one of the major revenue contributors of the Group's data-communication business in the foreseeable future. We will continue to reinforce our global R&D and manufacturing presence by optimizing our active product offerings and developing next-generation active products for the prosperous datacom market. Our dedication to developing new and innovative products will allow us to sustain development and generate lucrative returns for our shareholders."

About O-Net Technologies (Group) Limited (Stock code: 877)

O-Net Technologies (Group) Limited, with headquarter in Shenzhen, was listed on the Stock Exchange of Hong Kong Limited on 29 April 2010. It is a leading supplier of optical networking products to the global optical telecommunications and data-communications markets. To further strengthen the Group's leadership in the global technology industry, O-Net, along with 3SP and ITF, secures the supply of advanced laser chips and optical components in order to widen the Group's product range and improve its technologies through vertical integration. Riding on the Group's core optical networking technology platform, it has diversified from its core business to certain new businesses including automation, sensing and industrials, and has re-positioned its strategic focus from a sole telecom passive component supplier to a high technology leader with advanced products and solutions for cloud data centers, industrial laser, ADAS and consumer electronics markets with an aim to become a leading high-tech company.

Media enquiries:
Strategic Financial Relations Limited
Maggie Au +852 2864 4815 maggie.au@sprg.com.hk
Isabel Kwok +852 2864 4824 isabel.kwok@sprg.com.hk
Nelda Lai +852 2114 4903 nelda.lai@sprg.com.hk
Fax: +852 2527 1196 / 2804 2789

The largest commercial application of solid state ionics are lithium-ion batteries, which Sony commercialized around 1990.The lithium-ion batteries pictured were used in some of the early Kyocera cellular phones (image credit: Sony Energy Devices Corporation).

Takehiko Takahashi of Nagoya University was the first to coin the term 'solid ionics' in 1967.

Evolution of materials used in solid-state ionics: 1 - ideal crystals; 2 - crystals with point defects; 3a - crystals with structural disorder; 3b - ion-conducting glasses; 3c - polymer electrolytes; 3d - nanosized systems. This figure is taken from the preceding historical review on solid-state ionics published in STAM at http://doi.org/10.1088/1468-6996/14/4/043502.

Japanese researchers have helped discover, analyze and commercialize novel conducting materials and products, such as zirconia-based gas sensors and lithium-ion batteries.

Tsukuba, Japan, Sep 12, 2017 - (ACN Newswire) - The field of solid-state ionics originated in Europe, but Japanese scientists have significantly advanced it over the past 70 years, according to a review in the journal Science and Technology of Advanced Materials (STAM).

Solid-state ionics deals with all aspects of the migration of ions (charged atoms) in solids, such as ceramics, polymers, biomaterials and their composites. Despite a common belief that solids don't conduct ions, some solids with specific structural and physical properties exhibit a fast ionic conduction, which is comparable to that of liquids.

Takehiko Takahashi of Nagoya University was the first to coin the term 'solid ionics' in 1967. 'Solid-state ionics' first appeared in 1971 in another of his papers, and was likely a play on 'solid-state electronics', another rapidly growing field at the time.

Early research focused on characterizing the crystal structures of highly conductive materials like silver and copper compounds. Over the decades, researchers have expanded the understanding of ionic conduction in different compounds involving lithium, sodium-sulfur and perovskite structures. These findings have led to the development of a variety of sensors and batteries, many of which are designed or manufactured in Japan.

For example, Sony first commercialized lithium-ion batteries in 1990, the largest commercial application of this field. Widely used in mobile electronics, lithium-ion is also being targeted for renewable energy storage, which could continue to expand the market.

Japanese scientists were key in demonstrating the effectiveness of sodium-sulfur batteries. These high-energy batteries could have potential applications in renewable energy storage and electric vehicles. A Japanese company, NGK Insulators, Ltd., commercialized the batteries in 2002. Their systems have ranged from one-megawatt to 34.8-megawatts and help stabilize renewable energy production by storing excess power and providing it to the grid when demand increases.

Gas sensors made of solid zirconia electrolyte are another key application of solid-state ionics. These sensors measure the partial pressure of oxygen in exhaust gas from car engines. They help to control the combustion conditions (air/fuel ratio) and minimize the emission of NOx and CO pollutants. Today, Japanese companies supply more than two thirds of zirconia-based oxygen sensors in cars.

Research in the field continues towards applications in nanoelectronics. It also aims to bring down the cost of solid oxide fuel cells, which are one of the most promising technologies for generation of electric energy from natural gases, but are prohibitively expensive. Scientists are still hoping to discover "fast, novel, and even exotic ion conductors in the solid state," according to the review's author Osamu Yamamoto of Mie University in Japan.

Article information:
Osamu Yamamoto
"Solid state ionics: a Japan perspective"
Science and Technology of Advanced Materials, 2017; 18:1, 504-527.
http://doi.org/10.1080/14686996.2017.1328955

For further information please contact:
Osamu Yamamoto,
Graduate School of Engineering, Mie University, Japan
yamamoto@chem.mie-u.ac.jp

Journal information
Science and Technology of Advanced Materials (STAM), http://www.tandfonline.com/stam is an international open access journal in materials science. The journal covers a broad spectrum of topics, including synthesis, processing, theoretical analysis and experimental characterization of materials. Emphasis is placed on the interdisciplinary nature of materials science and on issues at the forefront of the field, such as energy and environmental issues, as well as medical and bioengineering applications

For more information about STAM please contact
Mikiko Tanifuji
Publishing Director
Science and Technology of Advanced Materials
Tanifuji.Mikiko@nims.go.jp

Press release distributed by ResearchSEA for Science and Technology of Advanced Materials.

Figure: Stereoscopic view with a heart viewer

Delivers effective learning with stereoscopic view that meticulously recreates various behaviors of the heart

TOKYO, Sep 12, 2017 - (JCN Newswire) - Fujitsu today announces that the University of Tokyo will use heart simulator viewers with stereoscopic displays compatible with virtual reality (VR)(1) technology in an electrocardiogram lecture for third year students in the Faculty of Medicine. This lecture, given by Associate Professor Toshiaki Nakajima of Dokkyo Medical University Heart Center, is scheduled for September 13.

The heart viewer utilizes as content the output data from a heart simulator jointly developed by Fujitsu and University of Tokyo using the K computer(2) as well as a computer cluster. In this lecture, students will be able to see for themselves the complexity of "excitation propagation," a phenomenon whereby electric stimulation from pacemaker cells spreads throughout the heart, with a stereoscopic, 360-degree view utilizing VR, allowing them to understand how electrocardiograms are created through this process. Fujitsu has also prepared simulation models recreating conditions such as cardiac infarction, which also enables students to review the differences in excitation propagation between a normal heart and a diseased heart.

Based on its use in the University of Tokyo's lecture, Fujitsu will proceed with the development of the heart viewer with an aim toward product commercialization within Fujitsu's fiscal 2017 (ending March 31, 2018) for use as a more effective educational tool while contributing to the advancement of medicine.

http://www.acnnewswire.com/topimg/Low_FujitsuStereoscopic.jpg
Figure: Stereoscopic view with a heart viewer

Background

Heart disease is currently one of the leading causes of death in developed nations (number 2 in Japan, number 1 in the US), and many treatment methods and treatment devices are being researched and developed every day.

The heart is one of the most intricate structures in the body, making it difficult to learn about its complex movements and flow of blood from textbooks and other literature. More specifically, it is said that gaining an understanding of the relationship between the waveforms shown on an electrocardiogram and excitation propagation, which medical students learn early in their studies, is particularly problematic. The contractions of the heart caused by the electrical stimulus conveyed from certain pacemaker-type cells that exist in the heart to the heart muscles are displayed in an electrocardiogram in the form of a signal. The electrocardiogram itself is normally represented with a graph. At the same time, textbooks and existing educational materials have not been able to faithfully communicate the propagation process because the electrical signal spreads across cardiac muscle in a complex manner, three dimensionally.

Fujitsu has now made it possible to use the data output from heart simulations that faithfully recreate the behavior of the heart for use as a teaching material. Moreover, by providing a stereoscopic view with VR, this technology supports the efficient teaching of medical students, enabling them to really see such factors as the interrelation between the graph shown on the electrocardiogram and the propagation of electrical signals, and the difference between the behaviors of the heart both in normal times and when diseased.

Lecture Details

1. Date
September 13, 2017 (Wednesday)

2. Location/Class
University of Tokyo Hongo Campus - Electrocardiogram lecture (by Associate Professor Toshiaki Nakajima)

3. Attending students
About 110 Faculty of Medical third-year students

4. Summary
Wearing 3D glasses, students will be able to see a stereoscopic view of the heart simulation models displayed by a projector. The lecturer will manipulate the models for both normal and abnormal states of electrical propagation while giving an explanation with some simple operations, including rotating the models 360-degrees or showing cutaways.

Details of the Heart Simulator

1. Precise 3D Models Generated with the K computer
The heart simulator, developed by Fujitsu and Tokyo University, was generated using the K computer or a PC cluster, based on actual images of hearts taken with MRI and CT scans, accurately simulating the activity of the heart from the muscle cell level. Using the dedicated viewer, which was made as a teaching material, allows one to see the heart simulator's data stereoscopically. As a result, it is now possible to use these 3D models to see not only the internal and external structure of the heart, but also such things as true-to-life heart muscle activity, detailed networks of blood vessels and the flow of blood, as well as the spread of electrical propagation.

2. Capable of Observation from Numerous Perspectives and a Variety of Simulations
Users can observe the 3D models, which realistically reproduce even the interiors of hearts, from a variety of perspectives, including rotating, expanding, and cutting away parts of the model. In addition, Fujitsu has not only prepared models of healthy hearts, but also simulated data of various heart diseases, including myocardial infarction, fatal arrhythmias, and left bundle branch blocks, enabling students to learn by comparing them with the activity of a normal heart.

Future Plans

Fujitsu will continue development of a greater variety of heart simulation models in light of the experience gained from this lecture, with the goal of offering this heart simulator viewer as educational software for sale to educational and medical institutions during fiscal 2017.

(1) Virtual reality
Technology that stimulates the user's senses to create a life-like environment whose functions are essentially the same as the real thing, even though it may have no form or its form may be different.
(2) K computer
A supercomputer and the core system of Japan's Ministry of Education, Culture, Sports, Science and Technology's High Performance Computing Initiative (HPCI), developed jointly by Fujitsu and RIKEN. When it went into general service in 2012, it had an estimated performance in the 10-petaflops range.

About Fujitsu Ltd

Fujitsu is the leading Japanese information and communication technology (ICT) company, offering a full range of technology products, solutions, and services. Approximately 155,000 Fujitsu people support customers in more than 100 countries. We use our experience and the power of ICT to shape the future of society with our customers. Fujitsu Limited (TSE: 6702) reported consolidated revenues of 4.5 trillion yen (US$40 billion) for the fiscal year ended March 31, 2017. For more information, please see http://www.fujitsu.com.

* Please see this press release, with images, at:
http://www.fujitsu.com/global/about/resources/news/press-releases/

Contact:
Fujitsu Limited
Public and Investor Relations
Tel: +81-3-6252-2176
URL: www.fujitsu.com/global/news/contacts/

Special specification "Final Edition" (options shown), Hilux Z grade, Land Cruiser Prado TZ-G grade (options shown)

Also partial redesign to Land Cruiser Prado and launch of FJ Cruiser with special specifications

Toyota City, Japan, Sep 12, 2017 - (JCN Newswire) - Toyota will reintroduce Hilux into the Japanese market after a 13 year hiatus, and make a partial redesign to Land Cruiser Prado, both of which will be launched through Toyota dealers(1) across Japan on September 12. In addition, special specifications have been designed for FJ Cruiser, which will be launched through Toyota dealers across Japan on October 16.

Since its first launch in 1968, Hilux has been sold in approximately 180 countries and regions worldwide. It enjoys popularity around the world, with cumulative global sales reaching 17.3 million units(2).

In introducing Hilux to the Japanese market, Masahiko Maeda, chief development engineer, said, "Sales in Japan ended in 2004, but there are still around 9,000 owners, mainly using them for work, and many people have called for its reintroduction. We especially hope to provide for the needs of such customers."

"Furthermore, I would like to propose to customers not only the functional value of objects but also their conceptual value, in terms of special experiences and time gained by their possessing. We realize that for various practical reasons, Hilux can be a difficult vehicle to choose--for example, being a Class 1 vehicle, it requires annual inspection, and it is subject to slightly higher expressway tolls."

"However, I believe that Hilux is a vehicle that embodies the joy of possessing distinctive objects which is due to its dignified appearance, together with a toughness forged in the real world. Furthermore, we hope to express an active lifestyle for baby boomers, a customer segment that want to enjoy an active life."

In addition to the advanced exterior which further strengthened its power and innovation, Land Cruiser Prado has evolved through the inclusion of the Toyota Safety Sense P collision avoidance assist package as standard in all grades. With the FJ Cruiser, we designate this special specification as the "Final Edition," and adopted a unique beige throughout the vehicle--both for exterior and interior, thereby enhancing its modernity.

http://www.acnnewswire.com/topimg/Low_Toyota91217.jpg
Special specification "Final Edition" (options shown), Hilux Z grade, Land Cruiser Prado TZ-G grade (options shown)

Vehicle Outline

Hilux
- The exterior expresses concepts of "tough yet emotional" with power and vigor. The interior features silver highlights throughout, and unified blue illumination, producing a sense of sophistication. For the exterior panels, five colors were selected, including Nebula Blue Metallic, and Crimson Spark Red Metallic, while the interior is black.
- It is equipped with a 2GD-FTV 2.4L diesel engine. Besides providing power performance demonstrating high torque even in the low revolution range, it also achieves excellent environmental performance through high heat efficiency. Not only does it achieve fuels efficiency of 11.8 km/L.
- It has been fitted with collision avoidance assist type pre-crash safety(2) with pedestrian detection function to recognize pedestrians as well as cars. Furthermore, lane departure alert(2) is installed to help prevent deviation from the traffic lane.
- It is equipped with a part-time 4WD system that allows the driver to select a driving mode with a dial operation designed with in consideration of safety factors. It is a two-wheel drive which boasts superior quietness and fuel efficiency performance, for driving in urban areas and on expressways, which can be switched to 4-wheel drive on rough terrain and slippery roads, thus combining comfort and performance. Also, driving power can be adjusted to suit the road conditions by using Hill-start Assist Control and Active Traction Control(2), or Downhill Assist Control(2). As a genuine 4WD vehicle, it has realized high driving performance for both on-road and off-road.
- It adopts a suspension system that boosts vibration damping in addition to a high strength frame that ensures excellent running stability and driving comfort both on-road and off-road.
- By setting the steel bumper at a low deck position, passengers can get up and down when loading and unloading. A large hand grip helps passengers to get in and out more easily.

Land Cruiser Prado
- The new exterior design further enhances strength and innovation
- The front adopts a hood-center shape that takes visibility into account, and exudes power by combining the large front grill and headlamps. Other new specifications include LEDs for the headlamps in all cars, and 19-inch aluminum wheels (machine-cut highlights and dark gray metallic paintwork)(3).
- The rear design represses protrusion of the combination lamp, and realizes a more stable positioning by modifying the garnish design.
- The interior has a more advanced design, in particular for the instrument panel
- Lowering the upper part of the air vent ring (air conditioning outlet) has improved visibility. In addition, the navigation has a thin, tablet-style design that emphasizes its modernity. Metal highlights have been added to the center cluster and meter panels to enhance the feel of high quality.
- The steering wheel is designed in consideration of ease of grip, and its unique decoration enhances a sense of unity with the instrument panel.
- It supports safe driving through inclusion of the "Toyota Safety Sense P" collision avoidance assist package and Drive-start Control as standard features, together with the new addition of the Blind Spot Monitor(4).
- The exterior panels adopt a total of nine colors including the new Blackish Ageha Glass Flake (optional) and Avant Garde Bronze Metallic. The interior specifications adopt two colors including Neutral Beige.
- For the first time, the Land Cruiser series uses Torsen5 LSD for the rear differential and the option to select between five driving modes (NORMAL, ECO, COMFORT, SPORT S, SPORT S +) to suit the driving conditions, included as standard on the TZ - G, to enhance driving pleasure.
- The diesel vehicle grade system has been revised, with the addition of a 7-seater to "TX" and a 5-seater to TX "L package.

FJ Cruiser
- This special "Final Edition" specification adopts unique beige for the exterior color, together with the seat upholstery, and the center cluster garnish. Furthermore, black paintwork has been used extensively in the interior and exterior, and special 20-inch aluminum wheels and side steps have been used, adding to the appeal.

1. Dealers:
Toyota dealers throughout Japan (Land Cruiser Prado: through Osaka Toyopet Co., Ltd. in that region)
2. Sales target for Japan:
Hilux - 2,000 units / year
Land Cruiser Prado - 1,800 units / month
FJ Cruiser - 200 units / month
3. Dealer launch events:
October 21 and 22

Assembly Plant
Hilux: Ban Pho Plant, Toyota Motor Thailand Co., Ltd.
Land Cruiser Prado, FJ Cruiser: Hamura Plant, Hino Motors Ltd.

(1) Under the Japanese Ministry of Land, Infrastructure, Transport and Tourism's JC08 test cycle
(2) Standard inclusion for "Z"
(3) Standard for the "TZ-G," optional for the TX "L package"
(4) Optional for the "TZ-G" and the TX "L package"
(5) Torsen is a trademark of JTEKT Corporation

About Toyota

Supported by people around the world, Toyota Motor Corporation (TSE: 7203; NYSE: TM), has endeavored since its establishment in 1937 to serve society by creating better products. As of the end of December 2013, Toyota conducts its business worldwide with 52 overseas manufacturing companies in 27 countries and regions. Toyota's vehicles are sold in more than 170 countries and regions. For more information, please visit www.toyota-global.com.

Contact:
Public Affairs Division
Global Communications Department
Toyota Motor Corporation
Tel: +81-3-3817-9926

Senior management of BII Railway Transportation Technology Holdings Company Limited, including (from the left) Mr. Wang Xinjiang, Chief Financial Officer, Ms. Xuan Jing, Chief Executive Officer & Executive Director, Mr. Guan Jifa, Chairman & Non-Executive Director, Mr. Cao Wei, Vice Chairman & Executive Director and Mr. Ren Yuhang, Non-Executive Director, officiate the toasting ceremony.

Complements Parent Company BII's "Collaborative Development Strategy in Beijing, Tianjin and Hebei"; Successfully Implements "Going Out" Strategy via PPP Projects

HONG KONG, Sep 12, 2017 - (ACN Newswire) - BII Railway Transportation Technology Holdings Company Limited (the "Company" or "BII Trans Tech," formerly known as "China City Railway Transportation Technology Holdings Company Limited," and together with its subsidiaries referred to as the "Group;" HKEX code: 1522.HK) today held an unveiling ceremony to mark formally the debut of its new name. Many investors were present to congratulate and witness the Company making a new milestone.

BII Trans Tech is the only overseas listed subsidiary of Beijing Infrastructure Investment Co., Ltd. ("BII"), the largest company directly under the State-owned Assets Supervision and Administration Commission of People's Government of Beijing Municipality ("Beijing SASAC"). With BII becoming its holding company in end of 2016, BII Trans Tech is an industrial group focusing on city rail-related operations including investment and financing, technology research and development, intelligent rail transport construction, operation and maintenance, and civil communication information transmission services. To highlight its corporate background and positioning, the Company changed its name to "BII Railway Transportation Technology Holdings Company Limited", effective 25 August, and its stock short name has also been changed to BII Trans Tech.

Mr. Guan Jifa, Chairman and Non-executive Director of BII Trans Tech, said, "Capitalizing on the strong background of its controlling shareholder BII, the Group shall be able to seize the opportunities presented by development of the city rail transit industry backed by the Chinese government, benefiting from Beijing's out-reaching development initiatives such as the Beijing Suburban Railway, integration of Beijing, Tianjin and Hebei, and the Xiong'an New Area Plan. In the face of such new opportunities, after careful consideration and exhibiting shrewd foresight, the Group's management decided to change the company name to BII Railway Transportation Technology Holdings Company Limited, a move that marked a new milestone and the beginning of a new chapter of development for the Group."

BII, the Group's major shareholder, focuses on businesses relating to the investment, financing as well as management of infrastructure (mainly rail transit network), and businesses including rail transit facilities and equipment manufacturing and information technology services, land development, property development and management, as well as operation and services of related resources. In addition, BII owns the Beijing Subway, and as at end of 2016, the Beijing rail transit system comprised 19 operating rail transit lines of 574 km long all together and transit lines being constructed at a record high length of 300 km. The subway system has the most lines among all city rail transit systems in China and is one of the longest city rail transit systems in the world. As the only overseas-listed arm of BII, the Group can capitalize on BII's integrated industrial chain and apply its critical strengths in BII's rail transit projects. Riding on BII's industry position, years of experience in operation and management of rail transportation, and integrated industrial chain model, the Company has ample room for development in Beijing as well as the rest of the country in the future.

Expansion of systems integration business
As for the systems integration business, BII Trans Tech endeavors to develop itself into a core provider of information systems services for rail transit. The business mainly focuses on system integration, consolidation, optimization and enhancement of information systems for rail transit. It provides core systems and products, and operation and maintenance services to ensure secure operation of rail transit and enhance operational efficiency. On the network level, the Company provides core systems, namely Automated Fare Collection Clearing Centre (ACC) and Traffic Control Centre (TCC); and for line operation, core systems and products such as automated fare collection system (AFC), ISCS, Platform Screen Door System (PSD) and Passenger Information System (PIS) are provided, while for maintenance, the Company provides multi-dimensional maintenance services.

In 2017, the Group's systems integration business operation maintained good development in its overall operation benefiting from the fare reform entering phase 2, the Line No.2 platform door project, the Beijing-MTR MLC project and Beijing SI station platform door project. In the rest of the country outside Beijing, armed with a mature business model and leading subway command center technology, the Group built the "strongest brain" for the Chengdu metro system - the Chengdu Coordination and Command Centre (COCC), with 23 railway lines to oversee in the future. Furthermore, the Group will continue to maintain the advantage it gained from launching the Shenzhen Network Operation Control Center (NOCC) project in 2016 and has expanded into new markets, such as Changchun.

Expansion of civil communications business
The civil communications business mainly covers provision of transmission network services to telecom operators, thereby enables subway passengers to enjoy smooth communications services meeting their demand for mobile connection. To date, the Group owns civil information technology assets at 180 stations along 16 Beijing Subway lines, which included the 174 stations along 15 lines the Group acquired between 2014 and 2016 and the six stations in phase 2 of the Changping Line for which an acquisition agreement was just signed. Developing alongside the rail transit network in Beijing, the Group's civil communications business has started investing in building communications transmission systems for eight new or extended lines.

For this business, the Company continues to develop new areas of operation, exerting in particular the following: leasing of fiber optic, construction and leasing of 10 Gigabit Ethernet for railway transport, and construction and leasing of cloud service for rail transit. The business is expected to bring continuous stable income to the Group in the future.

New business development
The Group also keeps developing new businesses. Regarding the airport express line, the Group and Beijing Mass Transit Railway Operation Company Limited have established Beijing City Metro Company Limited ("Beijing City Metro"), with registered capital of RMB500 million and the Group holding 49% equity interests. Beijing City Metro targets to engage mainly in investment, construction, operation, management, value-added services and property development of subway lines. At the end of May 2017, Beijing City Metro has acquired the right to the operating income, including income from fare, advertising and rental, of the airport express line of Beijing Subway.

Regarding railway businesses in other places, as the business expands, the Group now has a customer base in Shenzhen, Chengdu and Changchun. And, via its subsidiary in Hong Kong, it has expanded its business in Hong Kong, Singapore and Thailand. Furthermore, the Group has kept pace with the expansion of its parent BII and participated in more Public-Private Partnership ("PPP") projects of BII.

As for the business of subway science and technology, in 2016, the Group and Beijing Mass Transit Railway Operation Company Limited set up Beijing Metro Technology Development Co., Ltd. in which the Group holds 49% equity interests. This joint venture mainly engages in AFC development and maintenance business within the subway operating area.

Mr. Guan concluded, "Looking ahead, the Group will seize opportunities brought by city rail transit development, capitalizing on BII's integrated industrial chain as well as overseas capital markets, in its bid to gradually build a business with intelligent rail transit and related civil communications transmission services at the core. Based on its solid footing in Beijing and Hong Kong, the Group will push to grow its businesses nationwide. It will operate in complement with BII's 'Collaborative Development for Beijing-Tianjin-Hebei' and PPP 'Going Out' strategy, pushing forward works on all business fronts so that it may achieve quality breakthroughs as it transforms and develops."

About BII Railway Transportation Technology Holdings Company Limited

BII Railway Transportation Technology Holdings Company Limited ("BII Trans Tech" or "the Group", formerly known as "China City Railway Transportation Technology Holdings Company Limited") is the only overseas listed company controlled by Beijing Infrastructure Investment Co., Ltd. ("BII") directly under Beijing SASAC. It is an industrial group focusing on city rail related operations including investment and financing, technology research and development, intelligent rail transport construction, and operation and maintenance, and civil communication information transmission service. The Group was listed on the Growth Enterprise Market of the Hong Kong Stock Exchange on 16 May 2012 and transferred listed to the Main Board of Hong Kong Stock Exchange on 6 December 2013 under the stock code 1522.HK. The Group currently has more than 300 employees working in its six wholly-owned subsidiaries, two holding companies and four joint-stock companies.

Leveraging BII's well-integrated industrial setup and overseas capital markets, the Group has been able to seize opportunities brought by development of city rail transit construction and gradually build a business with intelligent rail transport and civil communications information transmission services at the core. Based in Beijing and Hong Kong, the Group boasts a business footprint that spans the entire country. Its core businesses cover city rail transit investment, financing, construction, operation and maintenance, providing services throughout the entire city rail development cycle. It also serves as a platform for BII to help develop the rail transit industry.

For more information about the Group, please visit http://www.biitt.cn/.

For Enquiries:
Strategic Financial Relations (China) Limited
Ms. Anita Cheung Tel: (852) 2864 4827
Ms. Jover Wong Tel: (852) 2864 4811
Ms. Jacqueline Tang Tel: (852) 2864 4846
Mr. Tommy Chan Tel: (852) 2864 4838
Email: sprg-bii@sprg.com.hk

- Brands spend spend 16% of marketing budgets on marketing technology
- Martech budgets expected to rise by 10% over next 12 months
- Brands believe budget limits investment, whilst agencies see a lack of technological understanding

LONDON, Sep 12, 2017 - (ACN Newswire) - New research assessing the current and future state of the martech industry, has found that the UK and US martech market is growing exponentially as demand for new tools continues to rise.

The survey released today by Moore Stephens, the top ten global accountancy firm, and WARC, the global authority on advertising and media effectiveness, questioned more than 500 UK and North American brands and agencies, and confirms a burgeoning martech industry.

The results show that on average, brands are spending 16% of their marketing budget on marketing technology. The research also reveals that the size of the martech industry for the combined UK and US markets is estimated at $34.3bn.

Marketers are most likely to be using a martech tool for email, with 85% currently doing so. The majority also use social media and CRM tools, whereas experience optimisation and collaboration tools are currently used by around a third (37%). However, both of the latter are set for a significant rise; the survey reveals an additional quarter will invest in experience optimisation and collaboration tools in the next year.

Investment demand is driven by dissatisfaction: half (50%) of those polled state they don't have the tools they need. When analysing by agency vs brand, six in ten (58%) agencies stated they don't believe their clients have what they need and don't fully utilise the martech tools they do have.

Reflecting this, many businesses are looking to increase the investment in marketing technology: nearly half (46%) of the UK businesses and more than one in three (38%) in the US are looking to increase their investment in the next 12 months. Only 7% of US businesses and 4% of UK firms are looking to decrease.

When considering what holds marketers back from implementing martech tools, limited budget is unsurprisingly the biggest barrier, with 42% stating so. For marketing and communications agencies, 57% said that the main barrier to investment is a lack of understanding of the marketing technology available. This is compared to just a quarter (25%) of brands polled.

Commenting on the findings, Damian Ryan, Partner, Moore Stephens, said: "We carried out this research to better understand the size of the market and the drivers behind its growth. It is only recently that martech has been given its own name, having previously been engulfed by the adtech umbrella.

"The growth of the market shouldn't come as a surprise to brands, agencies or anyone in the media industry. We are entering a new chapter of business, one that will be governed by trust and economic common sense.

"While the rise of digital has been utterly spectacular, it has brought about widespread mistrust in the marketplace and channels that underline its success. We've seen the phenomenon that is fake news, as well as adblocking and a general worrying absence of transparency.

"These are just some of the drivers leading organisations to invest in technologies to provide a greater sense of control. Martech is growing and we see it as the industry to watch for the foreseeable future for investment and product innovation alike."

Amy Rodgers, Research Editor, WARC, said: "The marketing technology market has grown at a phenomenal rate over the past few years as marketers are required to do more, at a faster pace, than ever before. Tools that can assist or automate parts of this job are in high demand, especially as the evidence for their return on investment grows. This research indicates that martech use in the UK and US is set to grow by 10% over the next year, a strong indication of the strength of a market that is continually consolidating and diversifying."

A summary of the martech report is available at http://content.warc.com/read-martech-report-2018-marketing-technology-market.

A webinar discussing the findings of the martech report will be held on 2 October 2017. Register at http://content.warc.com/register-for-the-warc-webinar-martech-2018-marketing-technology-industry

About WARC

- your global authority on advertising and media effectiveness

warc.com is an online service offering advertising best practice, evidence and insights from the world's leading brands. WARC helps clients grow their businesses by using proven approaches to maximise advertising effectiveness. WARC's clients include the world's largest advertising and media agencies, research companies, universities and advertisers.

WARC hosts four global and two regional case study competitions: WARC Awards, WARC Innovation Awards, WARC Media Awards, The Admap prize, WARC Prize for Asian Strategy and WARC Prize for MENA Strategy.

WARC also publishes leading journals including Admap, Market Leader, the Journal of Advertising Research and the International Journal of Market Research. In addition to its own content, WARC features advertising case studies and best practices from more than 50 respected industry sources, including: ARF, Effies, Cannes Lions, ESOMAR and IPA.

Founded in 1985, WARC is privately owned and has offices in the UK, U.S. and Singapore.

Contact:
Amanda Benfell
PR Manager, WARC
Email: amanda.benfell@warc.com
Tel: +44 (0) 20 7467 8125

HONG KONG, Sep 12, 2017 - (ACN Newswire) - FDG Electric Vehicles Limited is pleased to announce that the first American shipment of electric trucks began making its way to the United States today.

This is not only a significant milestone for FDG and Chanje, but also a significant milestone for the Chinese and American pure electric vehicle industries. FDG established Chanje as the international brand, as it resembles FDG's domestic brand Changjiang. The co-developed ground-up electric vehicles are internationally recognised, the quality are of international standards and the products are fully exportable. The commercial electric vehicles have been homologated in the U.S. and have also been qualified for California's Hybrid and Zero-Emission Truck and Bus Voucher Incentive Project (HVIP) eligibility list, indicating the products have earned full accreditations.

The U.S. is generally known to have extremely stringent requirements for new energy vehicle imports. The V8070 model exported to the U.S. is built and developed with the strictest standards and processes, and is forwardly-engineered for the U.S. market. The product has gone through a full year of system tests - from carrying out 47 American standardization certifications to conducting components design verification tests; and from conducting system performance tests to conducting road tests. Among the 20 tests that have been done, 5 tests were conducted directly on U.S. soil whilst the remaining 15 tests were conducted in China's most authoritative China Automotive Technology & Research Centre (CATARC) with on-site guidance from American experts.

The V8070 model is a forwardly-engineered pure electric vehicle built from the ground up. The V8070 has passed U.S. homologation tests and fully complies with American traffic regulations.

Mr. Zhong Cao, Chairman and Chief Executive Officer of FDG Electric Vehicles Limited said, "Today is an important date for the Chinese and American electric vehicle industry. I am very excited to bring FDG-made electric vehicles to the United States. We are going to seize every opportunity and to continue to focus on quality. Today's first shipment to the U.S. proves that we are a truly global pure electric vehicle manufacturer. We are very happy to bring FDG-made pure electric vehicles to the international stage for the first time."

Bryan Hansel, CEO, Chanje said "The early response to our medium-duty electric vehicles has been overwhelmingly positive. We already have volume orders and it is a momentous occasion that we can begin to fulfilling U.S. orders for a ground-up electric truck and clean up American fleets."

A new all-electric delivery truck is on the way, and it's not from Tesla

Chanje's vision sounds a lot like Tesla's: electric vehicles recharged via clean rooftop solar power.

But the new company has no interest in the automobile market. Instead, it's entering what it believes to be a lucrative niche in medium-duty electric trucks. Few such trucks exist. Most medium-duty electric trucks are internal-combustion vehicles hand-converted to run on electric motors and batteries. Chanje's trucks are not concept vehicles or prototypes. They're ready for sale, and the Los Angeles company plans to begin selling or leasing them within weeks.

Reported by Los Angeles Times:
Link: http://tinyurl.com/ybcfr22a

Chanje electric delivery truck from China to go on sale this year

A new electric-vehicle company called Chanje isn't focused on cars; instead, has set its sights on what it believes is a prime market for electric vehicles. That market is medium-duty delivery trucks, of which there are 7 million in the United States. About 500,000 new commercial-delivery trucks are sold each year. Chanje's electric truck, its sole U.S. product, is built from the ground up and differs from those created by companies that rely on retrofitting current commercial trucks. Although the company is based in California, its success also rides on China: Chanje is owned by Hong Kong's FDG, which makes battery cells and packs in mainland China. The electric delivery trucks are sold in China under the Changjiang brand name and a couple of thousand have already been delivered. Chanje's first electric trucks will be produced in China, though the company plans to move production to the United States if it finds the success it believes awaits.

Reported by Green Car Reports:
Link: http://tinyurl.com/ybfos8ur

About FDG Electric Vehicles Limited

FDG Electric Vehicles Limited ("FDG", stock code: 00729) is a vertically-integrated pure electric vehicle Original Equipment Manufacturer. The Group's core businesses include researching, designing and developing pure electric vehicles from the ground up, producing lithium-ion batteries, manufacturing cathode materials for lithium-ion batteries, as well as other direct investments. FDG controls the supply chain of producing pure electric vehicles and has evolved from a lithium-battery producer to a fully-integrated pure electric vehicle manufacturer. FDG aims to become a globally recognised producer of greener, quieter and more energy-efficient pure electric vehicles.

For further information about FDG, please visit FDG's website at http://www.fdgev.com.

About Chanje

Chanje is a California-based, privately held electric vehicle and energy solutions company that specializes in the last mile industry. FDG established Chanje as the international brand, as it resembles FDG's domestic brand Changjiang. Chanje is led by a diverse group of automotive industry experts and clean energy entrepreneurs. The Company's vision is to drive the evolution of sustainable solutions that improve the last mile. Chanje is the first company in North America that delivers large fleets of commercial electric trucks. Chanje will subsequently introduce energy services and a full range of electric vehicles including trucks, delivery vans and shuttle buses in a variety of lengths and capacities.

For more information, please visit Chanje's website at http://www.chanje.us/.

- Selection Reflects Strong ESG Performance -

TOKYO, Sep 12, 2017 - (JCN Newswire) - Mitsubishi Heavy Industries, Ltd. (MHI) has been selected for inclusion in the Dow Jones Sustainability Asia Pacific Index, one of the world's leading investment indices for ESG(1) performance. The Dow Jones Sustainability Indices (DJSI), developed by S&P Dow Jones and RobecoSAM, select companies based on various economic, environmental and social criteria to assess overall long-term sustainability.

MHI Group has consistently worked to resolve global challenges through its products and technologies, supporting industrial and social infrastructure. Its businesses span a wide range of regions and stakeholders and the Company is committed to pursuing sustainability, as reflected by its inclusion in the index.

"We are delighted to have been included in the DJSI Asia Pacific Index," said Masanori Koguchi, CFO and head of sustainability affairs for MHI. "Sustainability is a core focus of our business and this selection will encourage us to drive further positive change. Through our technology, our businesses and our people, we are addressing challenges like climate change and growing infrastructure demand. We will continue to pursue a more sustainable future going forward."

In addition to the DJSI, MHI has been included in two other prominent indices for sustainability investors. One is the FTSE Blossom Japan Index: a new index, established by the London Stock Exchange Group, which lists Japanese firms that excel in ESG performance. The other is MSCI Japan's Empowering Women Index (WIN), which identifies Japanese companies that are empowering women in the workforce and addressing diversity issues. Both of these indices have been adopted by Japan's Government Pension Investment Fund (GPIF) - the world's largest pension fund.

By protecting the global environment, building ties of trust with society, and supporting development for future generations, MHI will contribute to the realization of a sustainable society going forward.

(1) ESG - Environmental, Social and corporate Governance

About Mitsubishi Heavy Industries, Ltd.

Mitsubishi Heavy Industries, Ltd. (MHI), headquartered in Tokyo, is one of the world's leading industrial firms with 80,000 group employees and annual consolidated revenues of around 38 billion U.S. dollars. For more than 130 years, the company has channeled big thinking into innovative and integrated solutions that move the world forward. MHI owns a unique business portfolio covering land, sea, sky and even space. MHI delivers innovative and integrated solutions across a wide range of industries from commercial aviation and transportation to power plants and gas turbines, and from machinery and infrastructure to integrated defense and space systems.
For more information, please visit the MHI Group website: http://www.mhi-global.com.
For Technology, Trends and Tangents, visit MHI's new online media SPECTRA: http://spectra.mhi.com.

Contact:
Joseph Hood, PR Manager
Mitsubishi Heavy Industries, Ltd.
Email: mhi-pr@mhi.co.jp
Tel: +81-(0)3-6716-2168
Fax: +81-(0)3-6716-5860

Mr. Lau Pong Sing, Chairman, Chief Executive Officer and Executive Director of AP Rentals (right) and Mr. Mitsuya Shinji, Director, AP Equipment Rentals (Singapore) Pte. Ltd (left).

Established a Wholly-owned Subsidiary in Singapore to Seize Development Opportunities Presented by Belt and Road Initiative

HONG KONG, Sep 12, 2017 - (ACN Newswire) - AP Rentals Holdings Limited ("AP Rentals" or the "Group" ; Stock Code: 1496), a leading equipment rental-related solutions provider in Hong Kong, has established a wholly-owned subsidiary in Singapore to expand into the Southeast Asian market and to seize business opportunities presented by the PRC's "Belt and Road" initiative.

Hong Kong and Macau have been the primary markets of the Group. However, in view of increasingly stringent environmental requirements imposed by the Hong Kong Government on the construction industry, the Group has been planning over the past years to expand overseas, and believes this year would be the right time to do so. In March 2017, AP Rentals established a wholly-owned subsidiary, AP Equipment Rentals (Singapore) Pte. Ltd. ("AP Singapore"), in Singapore - and appointed Mr. Mitsuya Shinji as AP Singapore's director. Through this subsidiary, the Group will be able to expand its construction equipment trading business into Southeast Asian countries by disposing of aged machinery with lower utilisation rate in such markets. Driven by the PRC's "Belt and Road" national development initiative, Southeast Asian countries have increased investment in infrastructure, resulting in strong demand for construction equipment. The disposal of the aforementioned equipment is expected to bring additional income to the Group and also helps streamline its fleet, thereby reducing maintenance and storage costs and associated depreciation expenses. Proceeds from the disposals will be used for re-investment, improving facilities for equipment maintenance, and installing a GPS equipment monitoring system to further raise the efficiency and quality of its equipment rental service.

Mr. Lau Pong Sing, Chairman, Chief Executive Officer and Executive Director of AP Rentals, said, "AP Rentals has been actively searching for opportunities to venture into new markets. In recent years, the Group has charted the changes in the Hong Kong and Southeast Asian markets, and has devised strategic plans to capture business opportunities arising from such changes. As one of the founding members of ASEAN, Singapore is in close proximity to the other ASEAN member states and has built close ties with them. The Group set up its subsidiary in Singapore in view of the strategic advantage. The expansion will bring new breakthroughs to the Group's business by further extending its influence in all of the Southeast Asian countries along the "Belt and Road" route. The Group will also be able to serve markets in close proximity to such countries and keep abreast of market needs. Mr. Mitsuya Shinji possesses years of experience in the construction machinery trading and rental industry and has maintained close ties with Japanese companies in the region. Through his involvement, the Group should be able to develop closer relations with its Japanese partners and to better penetrate the Southeast Asian market. This market has already responded favourably to the Group's new business - a business that will expand the Group's foundation for development and greatly contribute to its long-term advancement."

About AP Rentals Holdings Limited
AP Rentals Holdings Limited (stock code: 1496) is a leading equipment rental-related solution provider and was listed on the Main Board of the Hong Kong Stock Exchange in April 2016. The Group offers a wide range of construction, E&M engineering and event and entertainment equipment, equipment rental-related solutions with value-added services in Hong Kong. The Group's rental equipment principally covers power and energy equipment, high-reach equipment and material handling equipment. The Group has participated in numerous large landmark construction projects including some of the "Ten Major Infrastructure Projects" in Hong Kong, specifically the South Island Line, Shatin to Central Link, Tuen Mun-Chek Lap Kok Link and Tuen Mun Western Bypass, Kai Tak Development Plan, Guangzhou-Shenzhen-Hong Kong Express Rail Link and the Hong Kong-Zhuhai-Macau Bridge. For more details, please visit its official website: www.aprentalshk.com.

For media enquiries, please contact:
Strategic Financial Relations Limited
Keris Leung Tel: (852) 2864 4863 Email: keris.leung@sprg.com.hk
Davis Li Tel: (852) 2864 4892 Email: davis.li@sprg.com.hk

Contract signing between Rupert Pearce, CEO, Inmarsat and Masahiro Atsumi, Vice President & Senior General Manager, Space Systems, Mitsubishi Heavy Industries, Ltd.

TOKYO, Sep 12, 2017 - (JCN Newswire) - Inmarsat (LON: ISAT), the world's leading provider of global mobile satellite communication services, has today announced that Mitsubishi Heavy Industries, Ltd. (MHI) has been selected as the launch provider for the first satellite in the Inmarsat-6 fleet (Inmarsat-6 F1). The value of the contract has not been disclosed. The satellite, which is under construction by Airbus Defence and Space, is scheduled for launch in 2020 using MHI's H-IIA launch vehicle.

http://www.acnnewswire.com/topimg/Low_MHIInmarsat91217.jpg
Contract signing between Rupert Pearce, CEO, Inmarsat and Masahiro Atsumi, Vice President & Senior General Manager, Space Systems, Mitsubishi Heavy Industries, Ltd.

Inmarsat's sixth-generation (I-6) fleet will be the first to feature dual-payload satellites; each supporting L-band and Ka-band (Global Xpress) services. The I-6 satellites represent a step change in the capacity of Inmarsat's L-band services and will support a new generation of L-band capabilities, from advanced global safety services and very low cost mobile services, to Internet of Things (IoT) applications. The Ka-band payload will add further depth to Inmarsat's Global Xpress (GX) constellation, which began offering high-throughput broadband services worldwide in 2015. Through the I-6's Ka-band payload, Inmarsat will augment its global coverage with greater depth of capacity in regions of greatest demand.

"Inmarsat is delighted to select MHI and its H-IIA launch vehicle for the first of our sixth generation satellites," said Rupert Pearce, CEO of Inmarsat. "Inmarsat is continually seeking to extend and diversify its ecosystem of partners, particularly in the strategically important area of launch providers. We believe that MHI and its H-IIA launch vehicle offers a world-class service."

"With the development of the new H3 launch vehicle, it is clear that MHI is committed to continuing innovation," continued Rupert Pearce. "These are attributes that we seek in our partners and we look forward to a long and fruitful relationship with MHI as one of our roster of launch partners."

"We are honoured to have been selected by Inmarsat, a leader in the global mobile satellite communications industry, to provide launch services. The decision reflects the reliability and on-time delivery of our launches, as well as our highly valued technological expertise," said Masahiro Atsumi, Vice President & Senior General Manager for Space Systems in MHI. "As with previous launches, MHI will work closely and attentively - in the spirit of omotenashi - with Inmarsat to prepare the specifics of the launch to ensure that expectations are met. We hope to build a strong and lasting relationship with them, and to provide further launch services using our latest H3 rocket in future."

MHI Launch Services enjoys an extremely high success rate of 97.6% and has provided 35 successful consecutive launches since 2005, delivered on-time and to the customer's satisfaction. The successor to the H-IIA - the H3 Launch Vehicle - is now being developed by MHI and Japan Aerospace Exploration Agency (JAXA). It will allow even more flexible and cost-efficient launch services, and is scheduled to make its maiden flight in 2020.

The agreement with Inmarsat reflects MHI's long-term commitment to supporting a wide range of customers in the space industry. MHI will continue to support the development of the space industry, and will seek further new opportunities in this field both in Japan and globally.

Inmarsat will make a decision on its launch partner for the second I-6 satellite in due course.

About Mitsubishi Heavy Industries, Ltd.

Mitsubishi Heavy Industries, Ltd. (MHI), headquartered in Tokyo, is one of the world's leading industrial firms with 80,000 group employees and annual consolidated revenues of around 38 billion U.S. dollars. For more than 130 years, the company has channeled big thinking into innovative and integrated solutions that move the world forward. MHI owns a unique business portfolio covering land, sea, sky and even space. MHI delivers innovative and integrated solutions across a wide range of industries from commercial aviation and transportation to power plants and gas turbines, and from machinery and infrastructure to integrated defense and space systems.
For more information, please visit the MHI Group website: http://www.mhi-global.com.
For Technology, Trends and Tangents, visit MHI's new online media SPECTRA: http://spectra.mhi.com.

Contact:
Joseph Hood, PR Manager
Mitsubishi Heavy Industries, Ltd.
Email: mhi-pr@mhi.co.jp
Tel: +81-(0)3-6716-2168
Fax: +81-(0)3-6716-5860

NEW YORK and TOKYO, Sep 12, 2017 - (ACN Newswire) - Valuation Research Group (VRG), the international affiliate of Valuation Research Corporation (VRC), a leading provider of independent valuation support, announced an affiliate agreement with Tanizawa Sogo Appraisal Co., Ltd. to offer global valuation and real estate services in Japan.

"Tanizawa Sogo Appraisal is one of the top three real estate appraisers in Japan, and we are proud to partner with them," said Bill Hughes, Senior Managing Director of VRC.

Tanizawa Sogo Appraisal Co., Ltd. has been in existence for more than 50 years and employs 140 professionals in seven offices across Japan. The real estate appraisal company currently values more than 3,000 properties annually. Their primary markets include REITs, real estate portfolios and large corporations. (www.tanikan.co.jp/en)

Said Hitoshi Kawafuji, Executive Director of Tanizawa Sogo Appraisal, "In addition to our real estate practice, we've developed a personal property and a financial professional practice and believe our affiliation with VRG will allow us to support more clients globally."

About VRG
VRG is an international valuation practice that furnishes expert and independent opinions of value for solvency, fairness, business enterprises, intangible assets, capital stock, equity interests, real estate, and fixed assets. VRG has a global network of nearly 1,000 professionals and dozens of offices throughout continental Europe and the United Kingdom, Brazil, China, Japan, India, Mexico, Canada, Argentina, Australia, and the United States. The U.S. practice operates as Valuation Research Corporation (VRC). www.vrg.net.

About VRC
VRC furnishes expert and independent opinions of value for business enterprises, intangible assets, capital stock, equity interests, real estate, and fixed assets, as well as concerning solvency and fairness. VRC has provided valuation services worldwide since 1975. VRC has locations in Atlanta, Boston, Chicago, Cincinnati, Milwaukee, New York, Princeton, San Francisco, and Tampa, as well as international affiliates in Argentina, Australia, Brazil, Canada, China, Colombia, Germany, Japan, India, Luxembourg, Mexico, Spain, and the United Kingdom. www.valuationresearch.com.

CONTACT:
Jennifer Dries
jdries@valuationresearch.com
+1-414-221-6235

TOKYO, Sep 12, 2017 - (JCN Newswire) - Eisai Co., Ltd. announced today that an oral presentation on the results of the renal cell carcinoma cohort from a Phase Ib/II clinical study of its in-house discovered and developed multiple receptor tyrosine kinase inhibitor lenvatinib mesylate (product names: Lenvima / Kisplyx, "lenvatinib") in combination with the Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside of the United States and Canada) anti-PD-1 therapy pembrolizumab (product name: KEYTRUDA) developed by was given at the European Society for Medical Oncology (ESMO) 2017 Congress(1), which took place in Madrid, Spain. This combination therapy is being jointly developed by both companies.

The presentation at the ESMO 2017 Congress highlighted an analysis of 30 patients with metastatic renal cell carcinoma enrolled in combined Phase Ib and Phase II parts as of March 1, 2017. Based on the results of the analysis (investigator review), the primary endpoint of the Phase II part, Objective Response Rate* at 24 weeks after treatment began (ORR Week24) was 63%, with tumor regression observed in 93% (n = 28) of patients since beginning treatment (baseline). A tumor response was observed regardless of whether patients had previously received treatment or not (see table below).

http://www.acnnewswire.com/topimg/Low_Eisai91117Table.jpg

Additionally, tumor response was observed regardless of whether PD-L1 was expressed or not. In this study, the most frequently observed adverse events (top 6) were diarrhea, fatigue, hypothyroidism, stomatitis, hypertension and nausea.

In 2012, the number of patients with renal cancer was estimated to be approximately 338,000 worldwide,including approximately 115,000 in Europe, 58,000 in the United States and 17,000 in Japan.(2) Renal cellcarcinoma comprises more than 90% of all malignancies of the kidney,(3) and originates from malignant cells in the lining of the tubules of the kidney. The incidence of renal cell carcinoma in people over 55 years of age is rising, and it is more likely to affect men than women. For advanced or metastatic renal cell carcinoma that is difficult to treat with surgery, the standard treatment is molecular targeted drug therapy.

However with low 5-year survival rates, this remains a disease with significant unmet medical need.
Eisai regards oncology as a key therapeutic area and is aiming to discover revolutionary new medicines with the potential to cure cancer. Eisai remains committed to providing further clinical evidence for this combination therapy aimed at earlier submission for renal cell carcinoma as it seeks to contribute further to addressing the diverse needs of, and increasing the benefits provided to, patients with cancer, their families, and healthcare providers.

*Objective Response Rate: The ratio of patients whose tumor size decreased by at least 30%
(Partial Response) or disappeared (Complete Response) after treatment.

About lenvatinib mesylate (product names: Lenvima, Kisplyx, "lenvatinib")

Discovered and developed in-house, lenvatinib is an orally administered multiple receptor tyrosine kinase (RTK) inhibitor with a novel binding mode that selectively inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors (VEGFR1, VEGFR2 and VEGFR3) and fibroblast growth factor (FGF) receptors (FGFR1, FGFR2, FGFR3 and FGFR4) in addition to other proangiogenic and oncogenic pathway-related RTKs (including the platelet-derived growth factor (PDGF) receptor PDGFRalpha; KIT; and RET) involved in tumor proliferation.

Currently, Eisai has obtained approval for lenvatinib as a treatment for refractory thyroid cancer in over 50 countries, including the United States, Japan, and in Europe. Additionally, Eisai has obtained approval for the agent in combination with everolimus as a treatment for renal cell carcinoma (second-line) in over 35 countries, including the United States and in Europe. In Europe, the agent was launched under the brand name Kisplyx for renal cell carcinoma.

Furthermore, in a Phase III clinical study (Study 304) comparing safety and efficacy of the agent versus sorafenib for the treatment of hepatocellular carcinoma, the agent achieved its primary endpoint of overall survival, meeting the statistical criteria for non-inferiority to sorafenib. Following the submission of applications in Japan (June 2017), the United States and Europe (July 2017), Eisai also plans to submit an application for lenvatinib for the treatment of hepatocellular carcinoma in China within the latter half of fiscal 2017.

Additionally, a Phase III clinical study (Study 307) of the agent in combination with either everolimus or pembrolizumab as a first line treatment for renal cell carcinoma is underway.

About Study 111

Study 111 is a multicenter, open-label Phase Ib/II clinical study being carried out in the United States to evaluate the efficacy and safety of lenvatinib in combination with pembrolizumab. The primary endpoint of the Phase Ib part was to determine the maximum tolerated dose. Thirteen patients with unresectable solid tumors (non-small cell lung cancer, renal cell carcinoma, endometrial cancer, urothelial cancer, head and neck cancer, and melanoma) who had progressed after treatment with approved therapies or for which there are no standard effective therapies available were administered 24 mg (3 patients) or 20 mg (10 patients) of lenvatinib orally daily, as well as 200 mg of pembrolizumab intravenously every three weeks. The Phase II part was conducted on patients with select solid tumors who had previously undergone less than 2 chemotherapy regimens, with a recommended dosage of 20 mg of lenvatinib daily and 200 mg of pembrolizumab every three weeks as determined based on the results of the Phase Ib part. The primary endpoint of the Phase II part was objective response rate at 24 weeks after treatment began, with secondary endpoints including objective response rate, disease control rate, progression-free survival, and duration of response. Currently, the Phase II part is underway, with enrollment expanded for the endometrial cancer cohort.

In addition, Phase Ib clinical studies of lenvatinib in combination with pembrolizumab for the treatment of select solid tumors (Study 115) and hepatocellular carcinoma (Study 116) are ongoing in Japan.

About research on mechanisms of action in combination of lenvatinib and anti-PD-1 antibody

In a non-clinical study where mouse models were inoculated with mouse liver cancer, melanoma or colon cancer cell lines and treated with a combinartion of lenvatinib with an anti-mouse PD-1 antibody, synergistic anti-tumor activities were demonstrated.4 These are thought to be a result of an immunostimulatory response through a reduction in immunosuppressive tumor-associated macrophages and an increase in cytotoxic T lymphocytes by lenvatinib.

(1) Lee CH, et al. A Phase 1b/2 Trial of Lenvatinib + Pembrolizumab in Patients With Renal Cell Carcinoma. ESMO Congress Abstract, 2017; #847O
(2) GLOBOCAN2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/
(3) Eble J.N, et al. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs, World Health Organisation classification of tumours. (International Agency for Research on Cancer, Lyon, France in 2004)
(4) Kato Y, et al. Upregulation of memory T cell population and enhancement of Th1 response by lenvatinib potentiate anti-tumor activity of PD-1 signaling blockade : Lenvatineb and PD-1 mAb combination. AACR Meeting Abstract, 2017; #4614

About Eisai

Eisai Co., Ltd. (TSE:4523; ADR:ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit www.eisai.com.

Contact:
Public Relations Department,
Eisai Co., Ltd.
+81-3-3817-5120

TOKYO, Sep 12, 2017 - (JCN Newswire) - Eisai Co., Ltd. has announced that new findings indicating its in-house discovered and developed anticancer agent lenvatinib mesylate (product names: Lenvima / Kisplyx, "lenvatinib") delays deterioration in certain areas of health-related quality of life (QOL) in comparison to sorafenib were presented in an oral session at the European Society for Medical Oncology (ESMO) 2017 Congress(1), which took place in Madrid, Spain. These findings are based on an analysis of a Phase III study (REFLECT / Study 304)(2) for first-line treatment of unresectable Hepatocellular Carcinoma (HCC).

The oral presentation was based on the results of an analysis of responses to QOL questionnaires related to the symptoms, functioning, and overall well-being of patients enrolled in the REFLECT study. The European Organization for Research and Treatment of Cancer's (EORTC) health-related QOL questionnaires QLQ-C30 and QLQ-HCC18 were used for the assessment. While declined QOL was recorded in both the lenvatinib and sorafenib arms during the treatment. and for most domains the impact on QOL was generally similar between the two drugs, in the five domains of diarrhea (Hazard Ratio [HR] 0.53), general pain (HR 0.82), role functioning (HR 0.83), body image (HR 0.79) and nutrition (HR 0.81), lenvatinib demonstrated a delay in time to deterioration of QOL over the treatment period compared to sorafenib (nominal p
Cancer and cancer treatments greatly influence patient QOL, effecting ability to carry out roles in family life, utilize talents at work, and participate in general society. Appropriate monitoring of QOL and continuous treatment via anticancer agents allow for maximum patient benefit.

The QOL data accumulated in this study demonstrated the effects of different treatment methods on patients with HCC from a QOL perspective, and we anticipate that this information will support future decisions regarding appropriate treatment methods. Eisai remains committed to generating scientific evidence aimed at maximizing the value of lenvatinib as it seeks to contribute further to addressing the diverse needs of, and increasing the benefits provided to, patients with cancer, their families, and healthcare providers.

About lenvatinib mesylate (product name: Lenvima / Kisplyx, "lenvatinib")

Discovered and developed in-house, lenvatinib is an orally administered multiple receptor tyrosine kinase (RTK) inhibitor with a novel binding mode that selectively inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors (VEGFR1, VEGFR2 and VEGFR3) and fibroblast growth factor (FGF) receptors (FGFR1, FGFR2, FGFR3 and FGFR4) in addition to other proangiogenic and oncogenic pathway-related RTKs (including the platelet-derived growth factor (PDGF) receptor PDGFRalpha; KIT; and RET) involved in tumor proliferation.

Currently, Eisai has obtained approval for lenvatinib as a treatment for refractory thyroid cancer in 50 countries, including the United States, Japan, and in Europe. Additionally, Eisai has obtained approval for the agent in combination with everolimus as a treatment for renal cell carcinoma (second-line) in over 35 countries, including the United States and in Europe. In Europe, the agent was launched under the brand name Kisplyx for renal cell carcinoma.

Following the submission of applications for the hepatocellular carcinoma indication in Japan (June 2017), the United States and Europe (July 2017), Eisai also plans to submit an application in China within the latter half of fiscal 2017.

A Phase III study of lenvatinib in separate combinations with everolimus and pembrolizumab in renal cell carcinoma (first-line) is underway. A Phase Ib/II study to investigate the agent in combination with pembrolizumab in select solid tumors (non-small cell lung cancer, renal cell carcinoma, endometrial cancer, urothelial cancer, head and neck cancer, and melanoma) is underway. Additionally, a Phase Ib study of the combination in hepatocellular carcinoma is also underway.

About the REFLECT Study (Study 304) 1, 2

The REFLECT study (A Multicenter, Randomized, Open-Label, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib (E7080) Versus Sorafenib in First-Line Treatment of Subjects With Unresectable Hepatocellular Carcinoma) is a multicenter, open-label, randomized, global Phase III study comparing the efficacy and safety of lenvatinib versus sorafenib. In the study, 954 patients were randomized in a 1:1 ratio to receive lenvatinib 12 mg (>/=60 kg) or 8 mg (
The primary endpoint of the study was Overall Survival (OS), with the goal of demonstrating non-inferiority. Other factors including Progression Free Survival (PFS), Time To Progression (TTP), Objective Response Rate (ORR) and Quality of Life (QOL) were assessed as secondary endpoints.

According to the results of the study, lenvatinib (13.6 months) met the statistical criteria for non-inferiority in the primary endpoint of median OS compared to sorafenib (12.3 months). (Hazard Ratio [HR] 0.92, 95% Confidence Interval [CI] = 0.79 - 1.06)

Additionally, lenvatinib showed statistically significant improvements in the three secondary efficacy endpoints, doubling sorafenib's median values and ratios: median PFS (lenvatinib 7.4 months versus sorafenib 3.7 months, HR 0.66, 95% CI = 0.57 - 0.77, P
Regarding QOL, when comparing clinically significant delays in time to deterioration for lenvatinib and sorafenib, an assessment based on EORTC QLQ-C30 indicated the following results (lenvatinib/sorafenib): diarrhea (4.6 months / 2.7 months, Hazard Ratio [HR] 0.53, 95% Confidence Interval [CI] = 0.449 - 0.630, nominal p
In this study, the five most common adverse events observed in the lenvatinib arm were hypertension, diarrhea, decreased appetite, weight loss and fatigue, which is consistent with the known side-effect profile of lenvatinib.

About Hepatocellular Carcinoma

Liver cancer is the second-leading cause of cancer deaths, estimated to be responsible for 750,000 deaths per year globally. Additionally, 780,000 cases are newly diagnosed each year. There is a large regional difference, with about 80% of new cases occurring in Asian regions, including China and Japan.(3) Hepatocellular carcinoma accounts for 85% to 90% of primary liver cancer cases. Hepatocellular carcinoma is associated with chronic liver disease, in particular cirrhosis. Major causes of cirrhosis include hepatitis B virus and hepatitis C virus. However, according to a recent investigation, non-B/non-C hepatocellular carcinoma is on the rise. Surgery is the first option for treatment, however, in many cases of recurrence after resection or when the cancer is deemed advanced at diagnosis, surgery is not applicable due to the disease having already metastasized throughout the body, and so it remains a condition with significant unmet medical needs. The only medicine approved for systemic therapy is sorafenib, making this a disease with unmet medical needs.

About EORTC QLQ-C30 and EORTC QLQ-HCC18

Questionnaires developed by the European Organisation for Research and Treatment of Cancer (EORTC) to assess QOL. EORTC QLQ-C30 consists of 30 items and is widely used in the field of oncology. EORTC QLQ-HCC18 consists of 18 items and is used for hepatocellular carcinoma patients.

(1) Vogel A et al. "Health-related quality of life and disease symptoms in patients with unresectable hepatocellular carcinoma treated with lenvatinib or sorafenib (REFLECT/Study 304)", the European Society for Medical Oncology (ESMO) 2017 Congress, (September 2017), Abstract No: 6180
(2) Cheng A et al. "Phase 3 trial of lenvatinib vs sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma", 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO), (June 2017), Abstract No: 4001
(3) GLOBOCAN2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/

About Eisai

Eisai Co., Ltd. (TSE:4523; ADR:ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit www.eisai.com.

Contact:
Public Relations Department,
Eisai Co., Ltd.
+81-3-3817-5120

TOKYO, Sep 12, 2017 - (JCN Newswire) - Eisai Co., Ltd. announced today that it has been selected for a fifth consecutive year of membership in the Dow Jones Sustainability Asia Pacific Index (DJSI Asia Pacific), the Asia Pacific version of the Dow Jones Sustainability Indices (DJSI), which are a family of premier global indices for socially responsible investment (SRI).

The DJSI family was jointly established between RobecoSAM AG (Switzerland) and S&P Dow Jones Indices LLC (United States) in 1999 as the first global SRI indices in the world and assesses the corporate sustainability performance of eligible member companies based on economic, environmental and social criteria. This year, the DJSI Asia Pacific has selected 152 companies leading the way in sustainability (72 of which are from Japan) from among the region's top 614 companies. Eisai received high scores particularly in categories such as Codes of Business Conduct, Product Quality and Recall Management, Labor Practice Indicators as well as Strategy to Improve Access to Drugs or Products.

In addition to the DJSI Asia Pacific, Eisai has been selected for the 16th consecutive year since 2002 as a member of the FTSE4Good Index Series, another global benchmark SRI index.

The Eisai Group's corporate philosophy is to give first thought to patients and their families, and increase the benefits that health care provides as well as address diverse healthcare needs worldwide. Guided by this philosophy, Eisai will continue to develop innovative new drugs and make them available to patients around the world as early as possible to fulfill its social responsibility and secure the trust of stakeholders.

About Eisai

Eisai Co., Ltd. (TSE:4523; ADR:ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit www.eisai.com.

Contact:
Public Relations Department,
Eisai Co., Ltd.
+81-3-3817-5120

TOKYO, Sep 12, 2017 - (JCN Newswire) - Eisai Co., Ltd. and MAMORIO, Inc. have announced that the MeMAMORIO(1) tracking tool to support people with dementia and seniors going out will be launched in Japan on September 13.

Me-MAMORIO is a small tag that utilizes the short-range wireless Bluetooth(2) communication standard. It is light weight and shaped like a round button. To make it easier for people with dementia and seniors to carry it around with them, it can be sewn into a jacket or hat or attached to a bag or wallet. When people with dementia and seniors carrying the Me-MAMORIO tag pass close to people in the community who have the corresponding application installed on their smartphones, or to fixed receivers which have been set up in stations and other areas, Me-MAMORIO's positional data is automatically sent to a server. Family members or related care workers can then confirm the positional data with their smartphones. Additionally, to prepare for emergency situations such as the sudden injury or illness of a Me-MAMORIO user, services such as a 24-hour hotline for emergency medical advice and a medical institution information service will be provided in collaboration with the Tokio Marine Group.

According to statistics provided by the Ministry of Internal Affairs and Communications, by the year 2025, in which the baby boomer generation will be aged 75 and over, there will be 36.57 million seniors aged 65 or over in Japan, accounting for 30% of the overall population. Additionally, the Ministry of Health, Labour and Welfare estimates that by the year 2025, one in five people aged 65 or over will suffer from dementia, increasing the number of dementia sufferers to approximately 7 million. Furthermore, according to statistics provided by the National Police Agency, of the missing persons reported to the police in 2016, 15,432 were people with dementia. This number has been increasing year after year since they began tracking it in 2012.

Eisai and Mamorio entered into an agreement to jointly develop Me-MAMORIO in July 2016, and with the cooperation of various stakeholders including local governments and community residents, conducted demonstrations aiming for implementation. The demonstrations revealed that modifying the shape and weight of tags to make them easier to carry and improving the accuracy of positional data were necessary to support people with dementia and seniors going out freely. Additionally, it was determined that in conjunction with the usage of Me-MAMORIO, it would be important to create a supportive environment, including a human network. Since 2008, Eisai has been collaborating with various stakeholders including local governments, healthcare professionals and care workers to build communities where people with dementia can live safely and with peace of mind. This includes disease awareness activities and interprofessional collaboration such as between healthcare professionals and care workers. With the use of Me-MAMORIO as the premise, Eisai aims to support the creation of community environments where residents can help watch over people with dementia and seniors to support them going out.

MAMORIO Inc. already possesses one of Japan's largest smartphone application networks, which was built up through sales of MAMORIO (another type of tag that uses the same IoT tag technology as MeMAMORIO to track lost items), and fixed receivers which have been set up in "MAMORIO Spots", such as stations and department stories, to pick up positional data from tags. These will also be usable for the rollout of Me-MAMORIO.

In addition to spreading Me-MAMORIO, Eisai and MAMORIO will work together to establish an environment where the community as a whole can look out for people with dementia and seniors, and realize a society where people with dementia and seniors can preserve their individuality and freely go out in the town they're used to living in.

About Eisai

Eisai Co., Ltd. (TSE:4523; ADR:ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit www.eisai.com.

Contact:
Public Relations Department,
Eisai Co., Ltd.
+81-3-3817-5120

Project 1 (Leasing Continued by Original Tenant)

Project 2 (Renovation for New Tenant)

Outline of the Renovated Facilities

- Joins up with subsidiary to support companies' CRE strategies -

TOKYO, Sep 13, 2017 - (JCN Newswire) - Mitsubishi Corporation (MC) and its wholly owned subsidiary Mitsubishi Corporation Urban Development (MCUD) are pleased to announce their joint entry into a new business segment focused on the renovation and development of large-scale industrial facilities for leasing. MCUD's recent acquisition and development of two facilities located in Ichikawa City in Chiba Prefecture, Japan signaled their first move. The facilities were primarily used as temperature controlled warehouses and processing centers which, upon renovation, are leased to companies engaged in operations that need such facilities. The total cost for developing the two facilities (including investments tenants made in equipment and internal structures as required for their operations) is around 10 billion yen. Projects involving the development of large-scale industrial facilities for specific purposes such as temperature controlled warehouses and processing centers is a first for MC and also a unique business proposition within the real estate industry.

MCUD was able to acquire the first facility, an old industrial complex that was constructed more than 25 years ago, although the owner at the time was initially reluctant, and managed to upgrade the equipment and renovate the complex without interrupting the tenant's operations, while ultimately facilitating improved operational efficiency and reducing operational costs. The second facility was only over 15 years old, but came with less flexibility in term of layout. However, MCUD was able to successfully attract a new tenant by making major interior and layout changes that would cater adequately to the tenant's needs after renovation.

Operational facilities run by companies from a range of industries currently account for around 430 trillion yen, or 20%, of Japan's 2.52 quadrillion yen domestic real estate market(1). However, an increasing number of these companies are turning to a corporate real estate (CRE) management strategy due to changes in the business environment such as the spread of ROA/ROE based management, and basic restructuring needs caused by industry consolidation and streamlining of operations.

MC and MCUD are seeking to actively support the CRE strategies of companies who need these kinds of facilities for their operations with the aim of providing optimal solutions to the challenges they faced in the owning or leasing of real estate. MC is in a particularly good position to provide this kind of support by drawing on its broad networks across a variety of industries, project management skills, expertise in construction and engineering, and real estate consultation capabilities. MC has in the past completed real estate development projects for a wide range of assets including retail facilities, logistics facilities, and condominiums. MC intends to further expand its real estate business by providing support for the CRE strategies of other companies as one of its core businesses, while leveraging its strengths as a global integrated business enterprise.

(1) Referred by "Action Plans for the Real Estate Investment's Market Growth" by MLIT June 21, 2017

Outline of the Renovated Facilities
http://www.acnnewswire.com/topimg/Low_MitsubishiRenovatedFacilities.jpg

Scheme Outline

http://www.acnnewswire.com/topimg/Low_Mitsubishi91317Project1.jpg
Project 1 (Leasing Continued by Original Tenant)

http://www.acnnewswire.com/topimg/Low_Mitsubishi91317Project2.jpg
Project 2 (Renovation for New Tenant)

About Mitsubishi Corporation

Mitsubishi Corporation (MC; TSE: 8058) is a global integrated business enterprise that develops and operates businesses across virtually every industry including industrial finance, energy, metals, machinery, chemicals, foods, and environmental business. MC's current activities are expanding far beyond its traditional trading operations as its diverse business ranges from natural resources development to investment in retail business, infrastructure, financial products and manufacturing of industrial goods. With over 200 bases of operations in approximately 80 countries worldwide and a network of over 500 group companies, MC employs a multinational workforce of nearly 60,000 people. For more information, please visit www.mitsubishicorp.com.

Contact:
Mitsubishi Corporation
Telephone: +81 3 3210 2171 
Facsimile: +81 3 5252 7705

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